Take I-85 North to Suwanee. Turn left onto I-985 North. Take Exits 20, 22, and 24 into downtown Gainesville.
From Greenville, S.C.
Take I-85 South to Jefferson, Georgia. Exit at U.S. 129. Turn right onto U.S. 129 North. Stay on 129 North to Gainesville.
From Dalton, Georgia
Take I-75 South to Canton, Exit on Highway 20. Take Hwy. 20 East to GA 369. Take 369 to intersection of 369 & 306. Turn left on Hwy. 306. Follow 306 to GA 53. Turn right onto GA 53. GA 53 will take you into Gainesville.
From Birmingham, Alabama
Take I-20 East to Atlanta. Before you get to Atlanta, take I-285 toward Chattanooga. Follow I-285 to GA 400. Take GA 400 North to Exit 17 (Hwy. 306). Turn right onto Hwy. 306. Go straight for about 8 miles until you dead-end into GA 53. Turn right onto GA 53. GA 53 will take you into Gainesville.